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However, this domain interaction may not occur in ApoE2 and ApoE3 due to the existence of Cys112 that buries Arg61 by helices 2 and 3, resulting in a lost connection with Glu255 (Dong et al., 1994

Nature 567 , 244248 (2019)

10.1039/c9fo01990a 86 LiL.XuJ

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Eur Rev Med Pharmacol Sci 24(18)

Acknowledgments We acknowledge the support from Sichuan Academy of Medical Sciences & Sichuan Provincial Peoples Hospital, University of Electronic Science and Technology of China, Luxian Peoples Hospital, China Pharmaceutical University